Re: [A-List] How "scientific" is science?

[Hayduke <hayduke@xxxxxxxxxxxxxxx>]

    QED

on 12/17/2005 10:00 AM, bar@xxxxxxxxxxx at bar@xxxxxxxxxxx wrote:

> The hiv virus is not documented at all. I challenge you to present one
> published scientific paper where it is claimed it has been found.

EMBO J. 2003 Apr 1;22(7):1707-15

    Structural organization of authentic, mature HIV-1 virions and cores.
Briggs JA, Wilk T, Welker R, Krausslich HG, Fuller SD.

The Wellcome Trust Centre for Human Genetics, Division of Structural
Biology, University of Oxford, Roosevelt Drive, Headington, Oxford OX3 7BN,
UK.

Mature, infectious HIV-1 particles contain a characteristic cone-shaped core
that encases the viral RNA and replication proteins. The architectures of
mature virions and isolated cores were studied using cryo-electron
microscopy. The average size ( approximately 145 nm) of the virion was
unchanged during maturation. Most virions contained a single core but
roughly one-third contained two or more cores. Consideration of the capsid
protein concentration during core assembly indicated that core formation in
vivo is template-mediated rather than concentration-driven. Although most
cores were conical, 7% were tubular. These displayed a stacked-disc
arrangement with 7-, 8-, 9- or 10-fold axial symmetry. Layer line filtration
of these images showed that the capsid subunit arrangement is consistent
with a 9.6 nm hexamer resembling that previously seen in the helical tubes
assembled from purified capsid protein. A common reflection (1/3.2 nm)
shared between the tubular and conical cores suggested they share a similar
organization. The extraordinary flexibility observed in the assembly of the
mature core appears to be well suited to accommodating variation and hence
there may be no single structure for the infectious virion.
PMID: 12660176 [PubMed - indexed for MEDLINE]


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